Tangential flow filter system for the filtration of materials from biologic fluids

A system for removing materials from cerebrospinal fluid (CSF) of a human or animal subject, the system including:

• a first fluid pathway;
• a filtration subsystem in fluid communication with the first fluid pathway, the filtration subsystem configured to filter cerebrospinal fluid;
• a permeate outlet fluid pathway in fluid communication with the filtration subsystem;
• a retentate outlet fluid pathway in fluid communication with the filtration subsystem;
• a pump configured to cause a volume of cerebrospinal fluid to be withdrawn from the human or animal subject and transferred along the first fluid pathway to the filtration subsystem for filtration into a permeate volume and a retentate volume, the pump and filtration subsystem further configured to cause the permeate volume to be transferred along the permeate outlet fluid pathway and to be returned to the human or animal subject, and to cause the retentate volume to be transferred along the retentate outlet fluid pathway to a waste container;
• and
• a plurality of sensors, cooperating with a processor located and configured to generate and receive data, including during filtration of the fluid through the filtration subsystem, indicating the volume of cerebrospinal fluid withdrawn from the human or animal subject, generate and receive data indicating the volume of permeate returned to the human or animal subject, and calculate a waste rate of the system, wherein the waste rate is the difference between the volume of fluid withdrawn from the subject and the flow volume of returned permeate returned to the subject over a period of time.