Polyvalent vaccines for staphylococcal & streptococcal infection
AssigneeUniversity of Tennessee Research Foundation
InventorOudessa Kerro Dego
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Abstract
Disclosed are methods of treating and/or inhibiting an intramammary infection in a mammalian subject. The methods included administering a therapeutically effective amount of surface-associated polypeptides from various bacteria. Also disclosed are methods for blocking or reducing infection in a mammal. Further disclosed are methods for reducing the rate of intra-mammary infection and/or mastitis in a dairy mammal. Methods of increasing milk production are also provided.
Claims20
A pharmaceutical composition comprising isolated surface-associated polypeptides, wherein said surface associated polypeptides are selected from the group consisting of Staphylococcus aureus surface-associated polypeptides (SASP), Staphylococcus chromogenes surface-associated polypeptides (SCSP) and Streptococcus uberis surface associated polypeptides (SUSP).
A polyvalent vaccine against intramammary infection comprising at least two isolated surface-associated polypeptides selected from the group consisting of Staphylococcus aureus surface-associated polypeptides (SASP), Staphylococcus chromogenes surface-associated polypeptides (SCSP) and Streptococcus uberis surface associated polypeptides (SUSP).
A method of inhibiting bacterial infection in a subject comprising administering a pharmaceutical composition comprising isolated surface-associated polypeptides to the subject, wherein said surface associated polypeptides are selected from the group consisting of Staphylococcus aureus surface-associated polypeptides (SASP), Staphylococcus chromogenes surface-associated polypeptides (SCSP) and Streptococcus uberis surface associated polypeptides (SUSP).
Dependencies are inferred from the claim text.