Heterocyclic compound for inducing degradation of g12d mutant kras protein

A compound of the formula (IA) or a salt thereof,

• wherein in the formula,
• A is CRA or N,
• RA is H or C1-3 alkyl,
• E is CH or N,
• G is CR2 or N, and
• R1 is naphthyl optionally substituted with OH or a group selected from the group consisting of the formula (II), the formula (III) and the formula (IV) below,
• wherein,
• R1a and R1b, which are the same as or different from each other, are H, methyl, F or Cl,
• R1c is F, Cl, methyl or ethyl,
• R2 is H, halogen, optionally substituted C1-3 alkyl, cyclopropyl or vinyl,
• R3 is —P-Q or V,
• P is —CH2—, —O— or —N(RP)—,
• RP is H or optionally substituted C1-3 alkyl, and
• Q is the formula (V) or the formula (VI) below,
• V is the formula (VII) below,
• each RQ, which is the same as or different from each other, is OH or C1-3 alkyl, wherein RQ is attached only to a carbon atom that is an atom forming a ring selected from the group consisting of an azetidine ring represented by the formula (V), a pyrrolidine ring represented by the formula (VI), and a piperazine ring represented by the formula (VII),
• (i) when A is CRA or (ii) when A is N, and E or G is N,
• V may be a 7-membered or 8-membered saturated or unsaturated bridged heterocyclic group in addition to the formula (VII),
• m is 0 to 2,
• R4 is optionally substituted C1-6 alkyl, a 4-membered to 6-membered optionally substituted saturated heterocyclic group containing one or two hetero atoms selected from the group consisting of oxygen, sulfur and nitrogen, 5-membered optionally substituted heteroaryl containing one to four hetero atoms selected from the group consisting of oxygen, sulfur and nitrogen, or 6-membered optionally substituted heteroaryl containing one to three nitrogen atoms,
• R5 is optionally substituted C1-6 alkyl, optionally substituted C3-6 cycloalkyl, or a 4-membered to 6-membered optionally substituted saturated heterocyclic group containing one hetero atom selected from the group consisting of oxygen, sulfur and nitrogen,
• R6a and R6b, which are the same as or different from each other, are H or optionally substituted C1-6 alkyl, or R6a and R6b may form together with the carbon to which they are attached, optionally substituted C3-6 cycloalkyl or a 4-membered to 6-membered optionally substituted saturated heterocyclic group containing one hetero atom selected from the group consisting of oxygen, sulfur, and nitrogen,
• R7 is H, halogen, C1-3 alkyl, —SO2CH3, C3-6 cycloalkyl, a 4-membered to 6-membered optionally substituted saturated heterocyclic group containing one or two hetero atoms selected from the group consisting of oxygen, sulfur, and nitrogen, 5-membered optionally substituted heteroaryl containing one to four hetero atoms selected from the group consisting of oxygen, sulfur, and nitrogen, or 6-membered heteroaryl containing one to three nitrogen atoms,
• LY is —O-(optionally substituted C1-3 alkylene)-, —S-(optionally substituted C1-3 alkylene)-, —SO2-(optionally substituted C1-3 alkylene)-, —NRY-(optionally substituted C1-3 alkylene)-, -(optionally substituted C1-3 alkylene)-O—, -(optionally substituted C1-3 alkylene)-S—, -(optionally substituted C1-3 alkylene)-SO2—, or -(optionally substituted C1-3 alkylene)-NRY—,
• RY is H or C1-3 alkyl,
• RP1 is OH or F,
• RP2a is H or F,
• RP2b is H,
• W is optionally substituted phenylene or 6-membered optionally substituted heteroarenediyl containing one to three nitrogen atoms,
• X is a bond, —CH2—, —O—, —S—, or —NR4x—,
• R4x is H or C1-3 alkyl,
• Y is phenylene or pyridinediyl, wherein the phenylene may be substituted with F,
• L is -(L1-L2-L3-L4)-,
• L1, L2, L3 and L4, which are the same as or different from each other, are a group selected from the group consisting of a bond, —O—, —NRL1—, optionally substituted pyrrolidinediyl, optionally substituted piperidinediyl, optionally substituted piperazinediyl, optionally substituted C1-3 alkylene, and C═O,
• RL1 is H or C1-3 alkyl, and
• Z is NH or 5-membered heteroarenediyl containing one to four hetero atoms selected from the group consisting of oxygen, sulfur and nitrogen,
• or Y-L-Z is the formula (VIII) below: