Substituted pyrazolyl compounds and methods of use thereof
AssigneeChinook Therapeutics Canada, Inc.
InventorsMarc-Olivier Andrew Boily, Jinyue Ding, David Andrew Powell, Juan Manuel Rueda Espinosa, Tao Sheng
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Abstract
Provided herein are compounds, compositions and methods useful for inhibiting lactate dehydrogenase (LDH) activity and for the treatment, prevention and amelioration of one or more symptoms of diseases or disorders related to LDH activity, or the accumulation of oxalate, including hyperoxaluria.
Claims42
A compound of Formula (I):
- or a pharmaceutically acceptable salt or solvate thereof,
- wherein X is —O— or —CH2—;
- Y is —O— or —S—;
- and
- R1 is hydrogen, hydroxyl, methyl, or CF3.
A compound selected from the group consisting of:
- or a pharmaceutically acceptable salt or solvate thereof.
The method of 21, wherein the glyoxylate- or oxalate-lowering therapeutic is an RNAi therapeutic.
A method of treating a disease or disorder associated with elevated oxalate levels, comprising administering to a subject having such disease or disorder, a therapeutically effective amount of a compound selected from the group consisting of:
- or a pharmaceutically acceptable salt or solvate thereof.
A method of lowering oxalate levels in a subject in need thereof, comprising administering to the subject a compound selected from the group consisting of:
- or a pharmaceutically acceptable salt or solvate thereof.
The method of treating kidney stone formation in a subject in need thereof comprising administering to the subject a compound selected from the group consisting of:
- or a pharmaceutically acceptable salt or solvate thereof.
The compound selected from the group consisting of:
- or a pharmaceutically acceptable salt or solvate thereof, for use in treating a disease or disorder associated with elevated oxalate levels.
Dependencies are inferred from the claim text.