White light scattering in optical biomolecule interaction analysis

Abstract

The invention is directed to a device for the detection of target molecules, comprising a transparent substrate provided with binding sites on one surface of the substrate, wherein the binding sites are capable of binding at least one target molecule at least one light source means for coupling light provided by the light source into the substrate, wherein at least a part of the light generates an evanescent field of light propagating along the surface provided with the binding sites, wherein the evanescent field of light is diffracted by target molecules bound to the binding sites, thereby creating a plurality of detection signals which are detected by at least one detector characterized in that the detection signals are space-filtered by at least one optical element located in the Fourier plane of the plane of the binding sites.

Dependencies are inferred from the claim text.