US 2025/0197853 A1 · SIRNA TARGETING ANGIOTENSINOGEN AND PHARMACEUTICAL USE OF SIRNA

Abstract

An siRNA targeting angiotensinogen (AGT) and a pharmaceutical use of the siRNA. Specifically, the present invention relates to the siRNA targeting an AGT gene, an siRNA conjugate or a dsRNA, a composition, and a pharmaceutical use of the siRNA. The present invention also relates to a pharmaceutical composition, a cell or a kit comprising the siRNA, and a method for the siRNA to treat and/or prevent AGT-related disorders (such as hypertension).

Claims21

Dependent claims

An siRNA, comprising a sense strand and an antisense strand forming a double-stranded region, wherein

the sense strand comprises at least 15 contiguous nucleotides and differs by no more than 3 nucleotides from any one of the nucleotide sequences of SEQ ID NOs:
1, 2, 3, 4, 5 and 6;
the antisense strand comprises at least 15 contiguous nucleotides and differs by no more than 3 nucleotides from any one of the nucleotide sequences of SEQ ID NOs:
7, 8, 9, 10, 11 and 12;
the siRNA targets angiotensinogen.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

18/710,716Filed 18 Nov 2021

Priority

CN 202111398206.019 Nov 2021

Published

19 Jun 2025

Term ends

Not estimatedThe source records don’t support an estimate.

Classification18 codes

A61P 9/10
Drugs for disorders of the cardiovascular system: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary…
C12N 15/113
DNA or RNA fragments; Modified forms thereof ; Non-coding nucleic acids having a biological activity: non-coding nucleic acids modulating the…
A61K 47/549
The modifying agent being an organic compound: sugars, nucleosides, nucleotides or nucleic acids
A61P 9/12
Drugs for disorders of the cardiovascular system: antihypertensives

Sirna targeting angiotensinogen and pharmaceutical use of sirna

Life of this patent

Sirna targeting angiotensinogen and pharmaceutical use of sirna

Life of this patent

Abstract

Claims21