Method of predicting whether a kidney transplant recipient is at risk of having allograft loss

A method for post-transplant algorithmic multi-parameter risk prediction based immunosuppressive treatment of a kidney transplant recipient, comprising the steps of:

• i) performing a computer-based multiple parameter, risk prediction process for the transplant recipient, obtaining a risk prediction score that indicates the transplant recipient's risk of allograft loss, comprising steps of:
• a) assessing for said transplant recipient a plurality of parameters, said parameters including:
• 1) time of posttransplant risk evaluation,
• 2) allograft functional parameters comprising estimated glomerular filtration rate and proteinuria,
• 3) allograft histological parameters comprising interstitial fibrosis and tubular atrophy (IFTA), microcirculation inflammation (glomerulitis and peritubular capillaritis), interstitial inflammation and tubulitis, and transplant glomerulopathy, and
• 4) recipient immunological profile comprising the presence and level of the immunodominant circulating anti-HLA donor-specific antibodies;
• b) computer-implemented executing an algorithm, within a network-based cloud system wherein a client computer communicates via a network with a server computer via a network browser that resides on and operates on the client computer, on data comprising the transplant recipient's parameters assessed at step (i) (a), wherein the computer-implemented executing of the algorithm provides an algorithm output, which comprises the risk prediction score indicating the transplant recipient's risk of allograft loss;
• ii) in response to the transplant recipient's risk prediction score indicating a high risk of allograft loss:
• a) administering to the transplant recipient a first therapeutic regimen that includes immunosuppressive triple therapy at first dosage levels, the first dosage levels being dosages that are in accordance with medical standards of immunosuppressive triple treatment of transplant recipients indicated at high risk of allograft loss, the triple therapy comprising administration of a corticosteroid at a corticosteroid first dosage level, a calcineurin inhibitor at a calcineurin inhibitor first dosage level, and an anti-proliferative agent at an anti-proliferative agent first dosage level,
• b) after a duration of administering the first therapeutic regimen to the transplant recipient, performing a follow-up instance of step i) on the transplant recipient, obtaining a follow-up risk prediction score, and
• c) administering a second therapeutic regimen in response to the follow-up risk prediction score indicating the transplant recipient being at low risk of allograft loss, the second therapeutic regimen being in accordance with medical standards of therapeutic maintenance dose immunosuppressive treatment of transplant recipients at low risk of allograft loss.