Benzene derivative

A compound represented by general formula (I)

• wherein:
• R1 represents (1) —R11—COOR12, (2) —R13—CONR14R15, (3) —R17—CN, (4) —R18—CONHS(O)2—R19, (5) —R20—CycD, or
• (6)
• wherein:
• ring 1 represents a 3- to 6-membered nitrogen-containing monocyclic saturated heterocyclic ring;
• R101 represents (1) a halogen atom, (2) a C1-4 alkyl group, or (3) a C1-4 haloalkyl group;
• and n represents an integer of 0 to 3, wherein, when n is 2 or more, a plurality of R1 1s may be the same as or different from each other;
• R11, R13, R16, R17, R18 and R20 each independently represent (1) a C1-6 alkylene group which may be substituted by 1 to 3 halogen atoms, (2) a C2-6 alkenylene group which may be substituted by 1 to 3 halogen atoms, or (3) a C2-6 alkynylene group which may be substituted by 1 to 3 halogen atoms, wherein, when the alkylene group, the alkenylene group or the alkynylene group is a branched chain, two C1-2 alkyl groups branched from a single carbon atom may together form a C3-5 saturated carbocyclic ring;
• R12, R14, R15 and R19 each independently represent (1) a hydrogen atom, (2) a C1-4 alkyl group or (3) a C1-4 haloalkyl group;
• CycD represents triazole or tetrazole;
• R2 represents (1) a halogen atom, (2) a C1-4 alkyl group or (3) a C1-4 haloalkyl group, and p represents an integer of 0 to 3, wherein, when p is 2 or more, a plurality of R2s may be the same as or different from each other;
• X represents (1) CH2 or (2) an oxygen atom;
• L1 represents (1) a linear C3-7 alkylene group which may be substituted by 1 to 4 RL1as, (2) a linear C3-7 alkenylene group which may be substituted by 1 to 4 RL1as, (3) a linear C3-7 alkynylene group which may be substituted by 1 to 4 RL1as, or (4) (a linear C1-3 alkylene group which may be substituted by 1 to 2 RL1as)-O-(a linear C1-3 alkylene group which may be substituted by 1 to 2 RL1as);
• RL1a represents (1) a halogen atom, (2) a hydroxyl group, (3) an oxo group or (4) a C1-2 alkyl group, wherein:
• when there are at least two RL1as, a plurality of RL1as may be the same as or different from each other;
• and when each of two RL1as bonded to a single carbon atom is a C1-2 alkyl group, the C1-2 alkyl group may form a C3-5 saturated carbocyclic ring in conjunction with the carbon atom to which the C1-2 alkyl group is bonded;
• represents a single bond, a double bond or a triple bond;
• R3 represents (1) a hydrogen atom, (2) a halogen atom, (3) a hydroxyl group, (4) a C1-2 alkyl group, or (5) a methylidene group, and q represents an integer of 0 to 2, wherein:
• when
• is a single bond and q is 2, a plurality of R3s may be the same as or different from each other;
• and when at least one of R3s is a methyl group, the methyl group may form cyclopropane in conjunction with a carbon atom in the adjacent L1;
• CycA represents (1) a C5-10 monocyclic or bicyclic carbocyclic ring or (2) a 5- to 10-membered monocyclic or bicyclic heterocyclic ring;
• R4 represents (1) a halogen atom, (2) a hydroxyl group, (3) a C1-4 alkyl group, (4) a C1-4 haloalkyl group, (5) a C1-4 alkoxy group, (6) a C1-4 haloalkoxy group, (7) a cyano group, or (8) a —SO2—C1-2 alkyl group, and r represents an integer of 0 to 6, wherein, when r is 2 or more, a plurality of R4s may be the same as or different from each other;
• L2 represents —R31-L3-R32—;
• L3 represents (1) —NR201—S(O)—, (2) —NR202—S(O)2—, (3) —NR203—C(O)—, (4) —CR204(OH)—, (5) —NR205—, (6) —S(O)— or (7) —S(O)2—;
• R201, R202, R203, R204 and R205 each independently represent (1) a hydrogen atom, (2) a C1-4 alkyl group, or (3) a C1-4 haloalkyl group, wherein the alkyl group or the haloalkyl group may be substituted by (1) a hydroxyl group, (2) an oxo group, (3) a C3-6 monocyclic carbocyclic ring, or (4) a 3- to 6-membered monocyclic heterocyclic ring;
• R31 and R32 each independently represent (1) a bond or (2) a C1-3 alkylene group which may be substituted by 1 to 3 substituents independently selected from the group consisting of a halogen atom, a hydroxyl group and an oxo group;
• CycB represents (1) a C5-10 monocyclic or bicyclic carbocyclic ring or (2) a 5- to 10-membered monocyclic or bicyclic heterocyclic ring;
• and
• R5 represents (1) a halogen atom, (2) a C1-6 alkyl group, (3) a C2-6 alkenyl group, (4) a C2-6 alkynyl group, (5) a C1-6 haloalkyl group, (6) a C2-6 haloalkenyl group, (7) a C2-6 haloalkynyl group, (8) a C1-6 alkoxy group, or (9) a C1-6 haloalkoxy group, and t represents an integer of 0 to 6, wherein, when t is 2 or more, a plurality of R5s may be the same as or different from each other, or a salt thereof,
• wherein the compound is not 3-[2-[(E)-5-[3-(benzenesulfonamido)phenyl]pent-4-enoxy]phenyl]propanoic acid.