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AssigneeGlaxosmithkline Biologicals SA
InventorsGiada BUFFI, Filippo CARBONI, Rossella CUFFARO, Immaculada MARGARIT Y ROS
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The present invention provides immunogenic compositions and vaccines comprising isolated gonococcal outer membrane vesicles (OMVs). Said isolated gonococcal OMVs display lipooligosaccharide (LOS) glycan structures comprising an oligosaccharide alpha-chain elongating from Hep I having at least four hexose monosaccharides (4Hex or 5Hex) and wherein said LOS is detoxified. The present invention relates to the use of said immunogenic compositions and vaccines in medicine and, more particularly, the use of said immunogenic compositions and vaccines in immunizing a subject against Neisseria gonorrhoeae infection.
An immunogenic composition comprising isolated gonococcal outer membrane vesicles (OMVs) obtained or obtainable from a genetically modified Neisseria gonorrhoeae bacterium said bacterium comprising genetic modification(s) that
The immunogenic composition of any preceding claim wherein the genetically modified Neisseria gonorrhoeae bacterium is derived from strain MS11, BG27, BG8, F62, FA1090, WHO-F, WHO-M, WHO-N, WHO-G, GC14, SK92-679 or GC_0817560.
An immunogenic composition comprising isolated gonococcal outer membrane vesicles (OMVs) wherein said composition substantially comprises OMVs that display lipooligosaccharide (LOS) glycan structures comprising an oligosaccharide alpha-chain elongating from Hep I having at least four hexose monosaccharides (4Hex or 5Hex) and wherein said LOS comprises a pentaacylated lipid A rather than a hexaacylated lipid A.
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Dependencies are inferred from the claim text.