Compounds and methods for treating oxalate-related diseases

A compound of structural Formula I

• or a salt, polymorph, or tautomer thereof, wherein:
• W is chosen from N, NH, S, O, and CCH3;
• X is chosen from NH, S, O, and CH;
• Y is N or NH;
• R1 is chosen from hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, and C1-C6 cycloalkyl;
• L is chosen from O, S, CH2, NH, NR4, S(O), SO2, and CR4═CR5;
• A is chosen from monocyclic or bicyclic aryl, and monocyclic or bicyclic heteroaryl;
• each R2 is independently chosen from C6-C10 aryl, 5-10-membered heteroaryl, C1-C6 alkoxy, C1-C6 alkyl, C3-C6 alkyl, C1-C6 alkylsulfonyl, C1-C6 alkylthio, C1-C6 haloalkoxy, C1-C6 haloalkyl, cyano, and halogen;
• n is 0, 1, or 2;
• R3 is chosen from 3-10-membered heterocycloalkyl, 5-10-membered heteroaryl, C6-C10 aryl, C1-C6 alkyl, C1-C6 sulfonyl, C3-C6 cycloalkyl, 3-10-membered heterocycloalkylalkyl, 5-10-membered heteroarylalkyl, C6-C10 arylalkyl, and C3-C6 cycloalkylalkyl;
• R4 and R5 are each independently chosen from hydrogen and C1-C6 alkyl, or R4 and R5, together with the atoms to which they are attached, form a cycloalkenyl;
• and
• each R6 is independently chosen from 4-6-membered heterocycloalkyl, 5-10-membered heteroaryl, amino, C1-C6 alkoxy, C1-C6 alkyl, C1-C6 alkylsulfonyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C3-C6 cycloalkylalkyl, carboxyl, cyano, halogen, hydroxyl, methyl-4-6-membered heterocycloalkyl, and phenyl;
• and
• m is 0, 1, 2, or 3.