Systems and methods for sample collection with reduced hemolysis

An apparatus for limiting stress in a flow of blood, the apparatus comprising:

• a first port configured to be coupled to a first adapter that is in fluid communication with a patient;
• a second port configured to be coupled to a second adapter that fluidically couples to a fluid reservoir;
• a plurality of chambers disposed between the first port and the second port, an inner surface of each chamber having a continuous curvature, the plurality of chambers including a proximal chamber having a first volume, a distal chamber having a second volume greater than the first volume, and a medial chamber between the proximal chamber and the distal chamber, the medial chamber having a third volume greater than the second volume,
• the plurality of chambers configured to (i) reduce a negative pressure within a portion of a flow path distal to the first port and (ii) facilitate a laminar flow of the blood through at least a portion of the flow path between the first port and the second port.

An apparatus for limiting stress in a flow of blood, the apparatus comprising:

• a first port configured to be coupled to a first adapter that is in fluid communication with a patient;
• a second port configured to be coupled to a second adapter that fluidically couples to a fluid reservoir;
• a plurality of chambers disposed between the first port and the second port, each chamber from the plurality of chambers defining an inner volume, a cross-sectional area of the inner volume of each chamber varying between a smaller cross-sectional area and a larger cross-sectional area with a continuous curvature based on a position along a longitudinal centerline of each chamber, the larger cross-sectional area associated with a center of each chamber from the plurality of chambers, the inner volume of the plurality of chambers varying along a longitudinal centerline between the first port and the second port,
• the plurality of chambers configured to (i) reduce a negative pressure within a portion of a flow path distal to the first port and (ii) facilitate a laminar flow of the blood through at least a portion of the flow path between the first port and the second port.