Aryl alkynamide derivatives

A compound of formula (I) or a salt thereof:

• wherein,
• Ring A is phenyl which may be optionally fused with 5-membered heterocyclyl, 6-membered heteroaryl containing one or two nitrogen atoms, pyrazolyl or 6-membered saturated or partially unsaturated heterocyclyl,
• Ring B is phenyl which may be optionally fused with phenyl or 6-membered heteroaryl containing one or two nitrogen atoms, 6-membered heteroaryl containing one or two nitrogen atoms, pyrazolyl or imidazolyl,
• Ra1 and Ra2 are independently H, C1-6 alkyl, —O—C1-6 alkyl, —O—C1-6 alkylene-C2-6 alkenyl, —O—C1-6 alkylene-C2-6 alkynyl, halogen, halogeno-C1-6 alkyl, —O-halogeno-C1-6 alkyl or —OH,
• Rb1 and Rb2 are independently H, C1-6 alkyl, —O—C1-6 alkyl, halogeno-C1-6 alkyl, —O-halogeno-C1-6 alkyl, halogen, —C1-6 alkylene-OH, —C1-6 alkylene-NRcRd, —C(═O)—NRcRd, —NRcRd, —CN or —OH,
• Rc and Rd are independently H, C1-6 alkyl, C3-8 cycloalkyl, —C(═O)—C1-6 alkyl, or —S(═O)2—C1-6 alkyl,
• or, Rc and Rd may be optionally linked to each other to form 4- to 7-membered saturated heterocyclyl together with the nitrogen atom to which Rc and Rd are attached, wherein the heterocyclyl may be optionally substituted with one or two Re,
• Re is C1-6 alkyl, —O—C1-6 alkyl or halogen,
• R1 is H, optionally substituted C1-6 alkyl, optionally substituted C3-8 cycloalkyl, optionally substituted 4- to 7-membered saturated heterocyclyl, optionally substituted phenyl or optionally substituted heteroaryl,
• R2 is C1-6 alkyl which is substituted with one or two R3, C3-8 cycloalkyl which is substituted with one or two R4, 4- to 7-membered saturated heterocyclyl which is substituted with one or two R5, or phenyl which is substituted with one or two R6,
• or, R1 and R2 are linked to each other to form 4- to 7-membered saturated heterocyclyl together with the nitrogen atom to which R1 and R2 are attached, wherein the heterocyclyl may be optionally fused with phenyl, and the heterocyclyl and/or the fused phenyl may be optionally substituted with one to three R7,
• each R3 is independently —OH, —O—C1-6 alkyl, —C(═O)—NH2, —C(═O)—NH—C1-6 alkyl, —C(═O)—N(C1-6 alkyl)2, —NH2, —NH—C1-6 alkyl, —N(C1-6 alkyl)2, —NH—C(═O)—C1-6 alkyl, —NH—S(═O)2—C1-6 alkyl, —NH—S(═O)2—C1-6 alkylene-OH, —NH—S(═O)2—C1-6 alkylene-C(═O)—OH, —S(═O)2—NH2, —S(═O)2—C1-6 alkyl or —S(═O)(═NH)—C1-6 alkyl,
• each R4 is independently —OH, —O—C1-6 alkyl, —C(═O)—NH2, —C(═O)—NH—C1-6 alkyl, —C(═O)—N(C1-6 alkyl)2, —NH2, —NH—C1-6 alkyl, —N(C1-6 alkyl)2, —NH—C(═O)—C1-6 alkyl, —NH—S(═O)2—C1-6 alkyl, —S(═O)2—NH2, —S(═O)2—C1-6 alkyl or —S(═O)(═NH)—C1-6 alkyl,
• each R5 is independently —OH, oxo or imino,
• each R6 is independently —C(═O)—OH, —S(═O)2—NH2, —S(═O)2—C1-6 alkyl, —S(═O)(═NH)—C1-6 alkyl or —NH—S(═O)2—C1-6 alkyl, and
• each R7 is independently C1-6 alkyl, —C1-6 alkylene-OH, —C1-6 alkylene-C(═O)—OH, C3-8 cycloalkyl, —OH, —O—C1-6 alkyl, —NH2, —NH—C1-6 alkyl, —N(C1-6 alkyl)2, —NH—C(═O)—C1-6 alkyl, —NH—S(═O)2—C1-6 alkyl, —S(═O)2—C1-6 alkyl, —S(═O)(═NH)—C1-6 alkyl, —C(═O)—OH, —C(═O)—NH2, —C(═O)—NH—C1-6 alkyl, —C(═O)—N(C1-6 alkyl)2, oxo, imino or 4- to 7-membered saturated heterocyclyl which may be optionally substituted with one or two oxo,
• provided that the compound of formula (I) is not the compound of formula (II), (III), (IV) or (IVa);