Therapeutical peptidomimetic
AssigneesUniversita' Degli Studi Di Roma “La Sapienza”, Consiglio Nazionale Delle Ricerche, Association FrançAise Contre Les Myopathies – Afm-TéLéThon
InventorsGiulia D'AMATI, Veronica MOREA, Annalinda PISANO, Elena PERLI, Maria Gemma PIGNATARO
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Abstract
The present invention relates to peptidomimetics of a short peptide from leucyl-tRNA synthetase, compositions comprising one or more of said peptidomimetics and their use for the treatment of syndromes caused by mutations of mt-tRNA (mitochondrial transfer RNA) genes, and medical treatments of said syndromes comprising the administration of said one or more peptidomimetics or compositions comprising the same.
Claims25
A peptide having the amino acid sequence SEQ ID NO 1 and/or a fragment thereof of at least 8 amino acids of length, or variants of said peptide or fragment, wherein said peptide entirely consists of d-amino acids;
- optionally further conjugated at the N-terminus with a mitochondrial (mt)-targeting sequence.
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Dependencies are inferred from the claim text.