Mri-based method for predicting degree of accumulation of biomarker associated with alzheimer's disease and companion diagnosis method using same

A method for providing information for companion diagnostics related to Alzheimer's disease treatments using medical imaging, the method comprising:

• an acquisition step of acquiring first cerebral cortical thickness data for each region of the subject's brain;
• a prediction step of calculating predicted values of amyloid and tau accumulation in each brain region of the subject using weight information and the first cerebral cortical thickness data;
• a first calculation step of calculating a first amyloid-tau score from the amyloid interaction value, which scores the interaction between amyloid accumulated in the first brain region and amyloid accumulated in a third brain region adjacent to the first brain region, and the tau predicted value in the first brain region;
• a second calculation step of calculating a second amyloid-tau score from the predicted values of amyloid and tau in the second brain region of the subject;
• a first comparison step of comparing the first amyloid-tau score with a first threshold value that distinguishes between positive and negative amyloid and tau in the first brain region;
• and
• a second comparison step of comparing the second amyloid-tau score with a second threshold value that distinguishes between positive and negative amyloid and tau in the second brain region,
• wherein the weight information is defined between one or more sets of second cerebral cortical thickness data and one or more sets of amyloid-tau data.