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US 2025/0166176 A1Published application
Methods and materials for imaging adipose tissue
AssigneeCellSight Technologies Inc.
InventorJelena Levi
Life of this patent
Estimating the term…
Abstract
Embodiments of the present disclosure provide compositions and methods for performing positron emission tomography (PET) and, more particularly, to compositions and methods for the development and use of 18F-based PET tracers for use in selected imaging techniques such as studies of agents selected to modulate adipose tissue physiology.
Claims15
A method of imaging adipose tissue in a subject comprising:
- (a) administering to the subject a compound having a formula:
- wherein a route of administration is selected so as to allow the compound to be phosphorylated by deoxycytosine kinase and deoxyguanosine kinase present in adipose tissue in the subject;
- and
- (b) imaging the subject, wherein detecting the presence of the compound corresponds to the presence of adipose tissue.
1 more element
A method of observing the effects of a test agent on the activation of adipose tissue cells, the method comprising:
- combining the adipose tissue cells with the test agent;
- observing the presence or absence of changes in the activation of the adipose tissue cells combined with the test agent;
- and
- comparing the activation of the adipose tissue cells combined with the test agent with control adipose tissue cells that have not been combined with the test agent such that the effects of the test agent on the activation of adipose tissue cells is observed.
1 more element
The method of claim 12, wherein the adipose tissue cells are combined with the test agent in vitro.
Dependencies are inferred from the claim text.