Systems and methods to identify and treat subjects at risk for obstetrical complications
AssigneesWayne State University, The United States of America as represented by the Secretary, Department of Health and Human Service
InventorsTinnakorn Chaiworapongsa, Roberto Romero, Sonia S. Hassan
Life of this patent
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Abstract
Provided are systems and methods for assessing the presence or risk of obstetrical complications, particularly those related to an angiogenic and anti-angiogenic imbalance. Also provided are methods of treating an angiogenic and anti-angiogenic imbalance with water-soluble statins, such as pravastatin.
Claims20
A method of treating an imbalance of angiogenic factor(s) and anti-angiogenic factor(s) in a pregnant female human subject, comprising administering to the subject an effective amount of a water-soluble statin, thereby treating the imbalance of angiogenic factors and anti-angiogenic factors.
A kit comprising protein and/or nucleotide sequences that bind to PIGF, sVEGFR-1, and sEng in a sample derived from a subject and directs diagnosis of the presence or risk of an angiogenic and anti-angiogenic imbalance based on a concentration of the bound protein and/or nucleotide sequences.
Dependencies are inferred from the claim text.