Nanostructure-forming polypeptides and uses thereof

A polypeptide that is a circular permutation of 153-50A, comprising an assembly domain,

• the assembly domain comprising, in N- to C-terminal order, a N-terminal polypeptide segment, a linking polypeptide segment, and a C-terminal polypeptide segment, wherein:
• I. a) the N-terminal polypeptide segment comprises residues 74-201 of SEQ ID NO:
• 1 or a variant thereof, and the C-terminal polypeptide segment comprises residues 1-73 of SEQ ID NO:
• 1 or a variant thereof;
• II. b) the N-terminal polypeptide segment comprises residues 107-201 of SEQ ID NO:
• 1 or a variant thereof, and the C-terminal polypeptide segment comprises residues 1-106 of SEQ ID NO:
• 1 or a variant thereof;
• or
• III. c) the N-terminal polypeptide segment comprises residues 128-201 of SEQ ID NO:
• 1 or a variant thereof, and the C-terminal polypeptide segment comprises residues 1-127 of SEQ ID NO:
• 1 or a variant thereof;
• wherein variants thereof are at least 50%, at least 60%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% identical to the reference sequence.