Systems and methods for producing a mixer
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsTrinh VO, Huyun CHEN, Amardeep Singh BHUPENDER BHALLA
Life of this patent
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Abstract
Systems and method for producing a small-scale mixer are provided. In some implementations, a method for includes obtaining dimensions of an at-scale mixer. The method also includes determining first dimensions of the small-scale mixer based on respective dimensions of the at-scale mixer. The method further includes determining second dimensions of the small-scale mixer independent of the dimensions of the at-scale mixer. Additionally, the method includes generating the small-scale mixer using the first dimensions and the second dimensions using a three-dimensional printer.
Claims21
-20. (canceled)
A method of validating a small-scale mixer, the method comprising:
- obtaining the small-scale mixer, wherein the small-scale mixer comprises a plurality of first dimensions based on a respective plurality of dimensions of an at-scale mixer, and a plurality of second dimensions independent of the plurality of first dimensions, wherein the plurality of second dimensions inhibits degradation of biopharmaceutical product mixed in the small-scale mixer;
- generating, using the small-scale mixer, a first volume of biopharmaceutical product;
- obtaining a second volume of biopharmaceutical product generated by the at-scale mixer;
- and
- comparing one or more physical parameters of the first volume of biopharmaceutical product generated by the small-scale mixer with the first volume of biopharmaceutical product generated by the at-scale mixer.
A method of validating a small-scale mixer, the method comprising:
- obtaining the small-scale mixer, wherein the small-scale mixer comprises a plurality of first dimensions based on a respective plurality of dimensions of an at-scale mixer, and a plurality of second dimensions independent of the plurality of first dimensions, wherein the plurality of second dimensions inhibits degradation of biopharmaceutical product mixed in the small-scale mixer;
- generating, using the small-scale mixer, a first volume of biopharmaceutical product;
- obtaining a second volume of biopharmaceutical product generated by the at-scale mixer;
- and
- comparing one or more physical parameters of the first volume of biopharmaceutical product generated by the small-scale mixer with the first volume of biopharmaceutical product generated by the at-scale mixer.
- generating, using the small-scale mixer, a third volume of biopharmaceutical product;
- obtaining a fourth volume of biopharmaceutical product generated by the at-scale mixer;
- and
- comparing one or more physical parameters of the third volume of biopharmaceutical product generated by the small-scale mixer with the fourth volume of biopharmaceutical product generated by the at-scale mixer.
Dependencies are inferred from the claim text.