Methods and systems for determining her2 status using molecular data

A computing system comprising:

• one or more processors;
• and
• one or more memories having stored thereon computer-readable instructions that, when executed, cause the computing system to:
• receive digital biological data;
• process the digital biological data corresponding to a patient using a trained multi-stage machine learning architecture, wherein the processing includes:
• (i) processing the digital data using a trained HER2-positive model to determine whether the digital biological data indicates that a HER2 status of the patient is HER2-positive;
• (ii) when the patient is not HER2-positive, processing the digital biological data using a trained HER2-low model to identify whether the HER2 status of the patient is HER2-low;
• and
• (iii) when the patient is not HER2-positive or HER2-low, designating the HER2 status of the patient as HER2-negative;
• generate, via one or more processors, a digital HER2-low status report corresponding to the patient;
• and
• causing, via a display device, the digital HER2-low status report to be displayed.

A computer-readable medium having stored thereon computer-executable instructions that, when executed, cause a computer to:

• receive digital biological data;
• process the digital biological data corresponding to a patient using a trained multi-stage machine learning architecture, wherein the processing includes:
• (i) processing the digital data using a trained HER2-positive model to determine whether the digital biological data indicates that a HER2 status of the patient is HER2-positive;
• (ii) when the patient is not HER2-positive, processing the digital biological data using a trained HER2-low model to identify whether a HER2 status of the patient is HER2-low;
• and
• (ii) when the patient is not HER2-positive or HER2-low, designating the HER2 status of the patient as HER2-negative;
• generate, via one or more processors, a digital HER2-low status report corresponding to the patient;
• and
• cause, via a display device, the digital HER2-low status report to be displayed.