Positive displacement pipette tip for motorized control automation or instrument system

A liquid handling system, comprising:

• a pipette tip having an interface portion and a pipette tip body, the interface portion having an inner wall and a receptacle, the pipette tip body having a fluid channel along the length of the pipette tip body, and the fluid channel having an opening at the distal end of the fluid channel;
• a pipette plunger positioned along the inside of the pipette tip, the pipette plunger having a plunger upper portion, a plunger centering portion, and a plunger tip having a distal tip portion, wherein the receptacle is adapted to receive the plunger centering portion, wherein the fluid channel is adapted to receive the distal tip portion of the plunger tip;
• and
• a zero-insertion force pipette tip clamping mechanism adapted to manipulate the pipette tip and pipette plunger.