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US 2025/0155437 A1Published application
Methods and systems for detecting human papillomaviruses (hpv) in biological samples
OwnerLaimonis A. Laimins, Conor Winslow Templetoninventors
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Abstract
Provided herein are methods and systems for detecting one or more human papillomaviruses (HPV) in a biological sample. The methods can include detecting binding of an antibody or antibody fragment to DNA-RNA hybrids.
Claims21
A method for detecting one or more human papillomaviruses (HPV) in a biological sample, comprising:
- exposing a biological sample to an antibody or antibody fragment that binds to DNA-RNA hybrids;
- detecting binding of the antibody or antibody fragment to DNA-RNA hybrids in the biological sample;
- and
- determining that the biological sample contains HPV based on the detecting binding of the antibody or antibody fragment to DNA-RNA hybrids in the biological sample.
1 more element
A method for detecting one or more human papillomaviruses (HPV) in a biological sample, comprising:
- exposing a first portion of the biological sample to an antibody or antibody fragment that binds to p16 protein;
- detecting binding of the antibody or antibody fragment to p16 in the first portion of the biological sample;
- exposing a second portion of the biological sample to an antibody or antibody fragment that binds to DNA-RNA hybrids;
- and
- detecting binding of the antibody or antibody fragment to DNA-RNA hybrids in the second portion of the biological sample.
2 more elements
Dependencies are inferred from the claim text.