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AssigneeKansas State University Research Foundation
InventorsPhillip E. KLEBBA, Salete M. NEWTON, Ashish KUMAR, Taihao YANG
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Methods, kits, and devices for detecting microbes in various samples. The methods, kits, and devices utilize a high affinity protein-based sensor, wherein the high affinity protein-based sensor comprises a high affinity binding protein and/or bacteria engineered with such a protein, with a detectable label that generates a detectable signal. The high affinity binding protein is specific for a microbe-associated compound secreted or produced by the target microbe When a biological sample containing or suspected of containing a microbe is contacted with the sensor, the presence of the microbe can be detected due to changes in the detectable signal in the assay over time, which correspond to interaction of the microbe-associated compound with the high affinity binding protein.
An in vitro method for detecting a microbe in a biological sample, said method comprising:
A kit for detecting a microbe in a biological sample, said kit comprising:
A device for detecting a microbe in a biological sample, said device comprising a multi-compartment microplate comprising a plurality of microwells, further comprising a high affinity protein-based sensor deposited in one or more of said microwells.
Dependencies are inferred from the claim text.