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US 2025/0154568 A1Published application
Methods of detecting analytes
Assignee10x Genomics Sweden AB
InventorsJonas Frisen, Patrik Stahl, Joakim Lundeberg
Life of this patent
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Assignee10x Genomics Sweden AB
InventorsJonas Frisen, Patrik Stahl, Joakim Lundeberg
Estimating the term…
Localized detection of RNA in a tissue sample that includes cells is accomplished on an array. The array include a number of features on a substrate. Each feature includes a different capture probe immobilized such that the capture probe has a free 3′ end. Each feature occupies a distinct position on the array and has an area of less than about 1 mm2. Each capture probe is a nucleic acid molecule, which includes a positional domain including a nucleotide sequence unique to a particular feature, and a capture domain including a nucleotide sequence complementary to the RNA to be detected. The capture domain can be at a position 3′ of the positional domain.
A system for performing spatial analysis of a nucleic acid in a biological sample, wherein the system comprises:
Dependencies are inferred from the claim text.