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US 2025/0154566 A1Published application
Spatially encoded biological assays
AssigneePrognosys Biosciences, Inc.
InventorMark S. Chee
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Abstract
The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.
Claims1
A composition comprising a substrate having a plurality of capture areas, wherein
- each capture area of the plurality of capture areas is at a different location on the substrate;
- wherein a capture area of the plurality of capture areas comprises a pair of probes immobilized on the substrate, wherein the pair of probes comprises:
- a first probe comprising an oligonucleotide sequence that is complementary to a target nucleic acid;
- and
- a second probe comprising an oligonucleotide sequence that is unique to the capture area within which the pair of probes is immobilized.
2 more elements
Dependencies are inferred from the claim text.