Adeno-associated viral vectors and uses thereof

The library of claim 12, wherein the library comprises an amino acid sequence motif selected from the group consisting of:

• [RQMT] [RNQP] [RQPS] [ANQGST] **G;
• [QTV] [ANQGKP] [RNGSTY] * [ARGT] * [GP];
• [RKSV] [FPS] ** [RT] [QGS] [GS];
• [GST] * [QT] [NQ]R*G;
• [TV] ** [NS]R[QGM]G;
• [RNQT] [ANPS] [RNS] ** [NQGS]G;
• T [NGS] **R[AQS]G;
• NR** [NG] [QG]A;
• R**QGGG (SEQ ID NO:
• 199501);
• [QF] [KS] [RN] ** [NP] [AP];
• QR**S [TV]A (SEQ ID NO:
• 199502);
• [QKM] *G[RSV] [KT] *G;
• [QMTV] [RN] * [ANV] [RQS] * [GS];
• [NQ]R[NGP] [NQS] **A;
• [QT] * [RT] [RT] * [NQG] [AG];
• NTR**SA (SEQ ID NO:
• 199503);
• QRP* [AS] * [AS];
• RQ**TNA (SEQ ID NO:
• 199504);
• QRP** [MV] [AS];
• [RN] *N[RS] *[QG]G;
• [MTV]R[PS] *[QT] *G;
• [RY]S*[QK] *Q[GS];
• MRG**MG (SEQ ID NO:
• 199505);
• [GV] *[NT] *R[QS]G;
• [ST] [RQ] [RS]T**A;
• R*S*STP (SEQ ID NO:
• 199506);
• QR**TNG (SEQ ID NO:
• 199507);
• Q*RQT*P (SEQ ID NO:
• 199508);
• [NQ]RQ*[GS] *A;
• TR**NNA (SEQ ID NO:
• 199509);
• [RT]S*[RQ] [QS] *A;
• GQ*RV*G (SEQ ID NO:
• 199510);
• T*TSR*G (SEQ ID NO:
• 199511);
• TRG**TG (SEQ ID NO:
• 199512);
• NR* [GT] * [TV]G;
• T*RT*SA (SEQ ID NO:
• 199513);
• MG*R*GA (SEQ ID NO:
• 199514);
• [NQ]R*[NQ]S*A;
• RQ*PT*A (SEQ ID NO:
• 199515);
• T*T*RSG (SEQ ID NO:
• 199516);
• T*RGS*P (SEQ ID NO:
• 199517);
• TR**TMG (SEQ ID NO:
• 199518);
• R*TS*SP (SEQ ID NO:
• 199519);
• N**QRSA (SEQ ID NO:
• 199520);
• [QT] [RK] *S* [TY]A;
• QR*PA*G (SEQ ID NO:
• 199521);
• RS*S*GG (SEQ ID NO:
• 199522);
• RTS*S*P (SEQ ID NO:
• 199523);
• TRQ*T*G (SEQ ID NO:
• 199524);
• QR*S*TG (SEQ ID NO:
• 199525);
• R*NS*SP (SEQ ID NO:
• 199526);
• MR*G*QS (SEQ ID NO:
• 199527);
• N**SRQG (SEQ ID NO:
• 199528);
• NR*ST*A (SEQ ID NO:
• 199529);
• RSQ*G*G (SEQ ID NO:
• 199530);
• T*RTN*A (SEQ ID NO:
• 199531);
• T*S*RMG (SEQ ID NO:
• 199532);
• TR**TQA (SEQ ID NO:
• 199533);
• and TRT**SG (SEQ ID NO:
• 199534);
• YSGK**G (SEQ ID NO:
• 199535);
• or polynucleotides encoding the same, where “*” represents any amino acid and square brackets denote a list of amino acids that may occur at a position;
• and/or
• wherein the library comprises an amino acid sequence motif selected from the group consisting of:
• [RQGKST] [ARNQGFPST] ** [ARNQGKMTV] [ANQGMSV]G;
• [{circumflex over ( )}ADCEHILKPW] [ARNQGKPS] [ARNQGKST] [ARNQKPSTV] **[NDGPS];
• [NQKMFSTY] [RNGKT] [{circumflex over ( )}CEHILKFSWY] ** [RNQKMPSTV] [ANDEPS];
• [{circumflex over ( )}ARDCEHILW] [RGLKPSY] * [NQGKPSTV] * [ANQGFST]G;
• [{circumflex over ( )}ARDCEHILPW] [ARQGKPT] [RQGKPST] ** [ANGMST]G;
• [{circumflex over ( )}ADCQEHILW] [NQGLKMPST] * [{circumflex over ( )}NCEHILMFWY] [ARNQGMTV] * [GS];
• [RGMY] [ANQGPS] [NQKPST] ** [ANGKMST]G;
• [NQGKFSTV] [RNQGKS] ** [ARNGKT] [NQGKFSYV] [ANDGS];
• [{circumflex over ( )}ARDCEHILFW] * [ARNQGKMPT] [RQGKPSTV] * [AQGST]G;
• [{circumflex over ( )}ARDCEHILPW] * [RNGKPST] * [ARNGKSV] [NQGKMST]G;
• [RNKT] [RNQPS] *[RQGPS] [RQGS] *[APS];
• [RNMPY] [RNQKPS] * [ANQTV] * [ANQGKTV] [DGPS];
• [NQGKMFTV] [ARQGKMPTV] [RNQGKPTY] * [ARQKMST] *G;
• [RNQMFST] [RNQGKT] *[ARNQPST] *[AQGSTY] [APS];
• [QGKMSTV] * [ARNQGKMPT] [RNQGKT] [ARNSTV] *G;
• [RMT] * [NQKT] * [ARQGT] [ANQS] [GP];
• [RKMSV] **L[ANQGKPS] [NGMSTV] [ANGKSTV] [DGS];
• [NQKMPTYV] * [ARGKPTV] [NGST] [RNQKST] * [GPS];
• [RNQKMSY] [RQKST] [ADQKPST] * [AKSTV] * [ADPS];
• [RK] ** [NG] [AS] [GT]A;
• [RQ] * [RNPST] [AQGST] [AQGSTV] * [GPS];
• R[QPS] *S* [QGV]G;
• [RKV] [NGKP] *N[ANGT] *G;
• [NQGLKFT] [NGKS] [QKMS] ** [ARQKSV] [ANDEG];
• [RQMS] * [RNQKST] [NPST] * [ARNQGMS] [DGP];
• [RKT] ** [PST] [QT] [ANG]G;
• [NQKMT] [ARDKPST] [RNGKP] *G*G;
• [RNQKMFT] [RDGKPST] [RNQGKPT] *[NQGST] *[AS];
• [RNQMST] [RNDQKST] [RGKPST] [AQGKPST] **[APSV];
• [QKT] * [KS] * [AQGS] [NQS] [AS];
• [KFV] * [ANK] * [ST] [KS] [AD];
• [RQKMTYV] [RNDKPS] [RQGPS] [NDQGPST] ** [GP];
• [NQMT]R*[NGPTV] [AQGS] *[GS];
• [QMSY] [RKP] **S[AQGKV] [ADGS];
• R[NS] ** [ANQ] [AQT]A;
• R[QS] **T [NQ] [AS];
• [RQ] * [KPT] [GST] * [ANQGT]G;
• [RN] [RQP] * [GPS]T*A;
• [RNMPT] * [RNGKST] [ANDQKPST] [RNGST] *A;
• K[QPS] *[NMS] *[QV] [GS];
• K*[NQG] *[NT] [AST]G;
• RN*Q*SG (SEQ ID NO:
• 199536);
• K* [ANGST] [NST] * [AMS] [GS];
• KT*S*GA (SEQ ID NO:
• 199537);
• [RKMT] [RQKPST]S*[ARSTV] *G;
• [KM] *N*GNA (SEQ ID NO:
• 199538);
• N**S [GT] [GM]A;
• K* [GPS] [GT] [AT] *A;
• [QG]K* [GTV] [AMS] * [AN];
• [RQT] * [RNQPT] [RNST] * [QGS]A;
• [NQ] [RK] ** [GS]TA;
• [TV] **NRQG (SEQ ID NO:
• 199539);
• R[AGPS] [NQPT] *[NGST] *G;
• R[MST]N**[QT] [GP];
• [RNQ] * [PT] [GT] [RS] *A;
• RS**NTG (SEQ ID NO:
• 199540);
• [RK] *[PS]G*[NQGT]A;
• Q*KSA*A (SEQ ID NO:
• 199541);
• KN*G*TA (SEQ ID NO:
• 199542);
• K*S*[AS]GA (SEQ ID NO:
• 199543);
• [NG]K*[AS] [GT] *A;
• [GV]NS*[RK] *G;
• KT*S*SA (SEQ ID NO:
• 199544);
• [RM] [KP] *[AS]S*G;
• VK**STG (SEQ ID NO:
• 199545);
• [QKT] [RQGMSTV] [AGKP] [NGST] **A;
• PR*AT*G (SEQ ID NO:
• 199546);
• TRS*T*M (SEQ ID NO:
• 199547);
• T**RQQA (SEQ ID NO:
• 199548);
• KN*S*SG (SEQ ID NO:
• 199549);
• RNS*[AG] *G (SEQ ID NO:
• 199550);
• R*S* [AS]T [PS];
• [RG] [KS]S* [GT] * [AG];
• QR*NS*A (SEQ ID NO:
• 199551);
• R*SN*TG (SEQ ID NO:
• 199552);
• R*[NS] *[GT]GG;
• RAP**NS (SEQ ID NO:
• 199553);
• R*NNS*G (SEQ ID NO:
• 199554);
• [NK] * [GKP] [GST] * [GS]A;
• QK*GT*G (SEQ ID NO:
• 199555);
• T**NRGG (SEQ ID NO:
• 199556);
• VK*AS*A (SEQ ID NO:
• 199557);
• K*P*TGG (SEQ ID NO:
• 199558);
• K**QNQG (SEQ ID NO:
• 199559);
• R*S*TAP (SEQ ID NO:
• 199560);
• K*S[NG] *[GS] [GS];
• R*SN*NA (SEQ ID NO:
• 199561);
• RMP**GA (SEQ ID NO:
• 199562);
• [RW] [ANP]N[AKS] **A;
• KT**SGG (SEQ ID NO:
• 199563);
• R*P*TGA (SEQ ID NO:
• 199564);
• N**QRSA (SEQ ID NO:
• 199520);
• K*[NQ]ST*A (SEQ ID NO:
• 199565);
• MKN[TV] **A (SEQ ID NO:
• 199566);
• KGNN**G (SEQ ID NO:
• 199567);
• TKP**AA (SEQ ID NO:
• 199568);
• TR*GT*G (SEQ ID NO:
• 199569);
• KN*G*SA (SEQ ID NO:
• 199570);
• K*ASS*A (SEQ ID NO:
• 199571);
• KLNS**G (SEQ ID NO:
• 199572);
• N**SRQG (SEQ ID NO:
• 199528);
• and
• QNR*A*P (SEQ ID NO:
• 199573);
• R*P*AGA (SEQ ID NO:
• 199574);
• RT**STP (SEQ ID NO:
• 199575);
• SRTT*NG (SEQ ID NO:
• 199576);
• T*RT*NA (SEQ ID NO:
• 199577);
• TK*NS*G (SEQ ID NO:
• 199578);
• TRP**AA (SEQ ID NO:
• 199579);
• or polynucleotides encoding the same, where “*” represents any amino acid, square brackets surrounding a list of amino acids not preceded by the symbol “{circumflex over ( )}” denote a list of amino acids that may occur at a position, and square brackets surrounding a list of amino acids preceded by the symbol “{circumflex over ( )}” denote a list of amino acids that may not occur at a position.