Method for inducing dedifferentiation of adipocytes

Abstract

The present invention investigates the effects of hypertonicity on adipocytes, revealing its role in inducing the release of mitochondrial extracellular vesicles (MEVs). This release subsequently enhances the secretion of TNF-α, a pro-inflammatory cytokine crucial during stress responses, thereby activating the Wnt/β-catenin signaling pathway responsible for adipocyte dedifferentiation. Through the present method, hypertonicity induces MEVs release and TNF-α secretion, ultimately modulating Wnt/β-catenin signaling and promoting adipocyte dedifferentiation, offering promising therapeutic implications.

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