Combination bcl11a enhancer editing

A ribonucleoprotein (RNP) complex comprising a DNA endonuclease enzyme and at least two guide RNAs (gRNAs) that targets and hybridizes to a target sequence on a DNA molecule, wherein each of the at least two gRNAs hybridizes at least two genomic DNA locations selected from human chromosome 2 at location 60725424 to 60725688 according to GRCh37/hg19 human genome reference build (+55 functional region);

• human chromosome 2 at location 60722238 to 60722466 GRCh37/hg19 human genome reference build (+58 functional region);
• or human chromosome 2 at location 60718042 to 60718186 according to GRCh37/hg19 human genome reference build (+62 functional region).

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-10. (canceled)

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-42. (canceled)