US 2025/0154446 A1 · MAGNET-DRIVEN BISTABLE DYNAMIC BIOREACTOR

Abstract

A magnet-driven bistable dynamic bioreactor, its manufacturing method, and application thereof are provided. The bioreactor has a magnet-driven bistable actuator, a magnetic field generation module, and a connected temperature control module. The magnet-driven bistable actuator includes a magnetic bistable arch membrane. The magnetic field generation module provides a direction-alternating magnetic field, which drives the magnetic bistable arch membrane to switch states between different configurations. This process applies adjustable frequency biaxial bi-directional loading on cells that cultured on membrane, simulating real tissue loading. The temperature control module regulates the temperature of the magnet-driven bistable actuator. The bioreactor enables adjustable frequency biaxial bi-directional loading on cells cultured on the magnetic bistable arch membrane by utilizing an alternating magnetic field to switch its configuration. This process effectively simulates the loading environment experienced by cells in real tissues.

Claims18

Dependent claims

A magnet-driven bistable dynamic bioreactor comprises:

one magnet-driven actuator,
which includes a magnet-sensitive arch membrane, a fixed periphery, a bracket frame, and supporting component wherein the magnet-sensitive arch membrane is capable of snapping through and snapping back by application of magnetic field, enabling cell cultivation;
a magnetic field generation module,
wherein the magnetic field generation module provides a magnet field to drive the actuator;
and a temperature control module;
wherein the temperature control module adjusts the temperature of the culture medium.

3 more elements

Dependencies are inferred from the claim text.

Magnet-driven bistable dynamic bioreactor

Life of this patent

Magnet-driven bistable dynamic bioreactor

Life of this patent

Abstract

Claims18