Novel methods of therapy
OwnerTiffany Thorninventor
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Abstract
The present invention relates to compositions for use in the treatment of a malignancy, wherein the composition comprises an agent that binds CD33 and B7H4. The present invention also relates to combinations agents targeting the protein pairs.
Claims57
A composition for use in the treatment of a malignancy, wherein the composition comprises an agent that binds to CD33 and B7H4.
The composition for use according to any preceding claim, wherein the agent is an antibody or antigen binding fragment thereof.
The composition for use according to any preceding claim, wherein the agent is a bispecific antibody or antigen binding fragment thereof that binds CD33 and B7H4.
The composition for use according to a preceding claim, wherein the composition further comprises a payload.
A bispecific antibody or antibody fragment capable of binding CD33 and B7H4 for use in the treatment of cancer.
A method for treating a malignancy comprising administering to a subject in need thereof an agent that binds to CD33 and B7H4.
A method of targeting cells that express both CD33 and B7H4 comprising administering to a subject an agent that binds to CD33 and B7H4.
A combination of agents for use in the treatment of a malignancy, wherein the cell inhibiting agents bind to CD33 and B7H4.
The combination for use according to claims 36 to 46, wherein the agents further comprises a linker for linking the payload to the agent that binds to CD33 and B7H4 expressed on the cell surface.
A bispecific antibody or antigen binding fragment thereof capable of binding CD33 and B7H4.
Dependencies are inferred from the claim text.