Fully human monoclonal antibodies against human progranulin

An isolated antibody or antigen binding fragment thereof, comprising:

• a) a heavy chain variable (VH) region comprising the CDR sequences SEQ ID NOs:
• 1, 2, and 3 and a light chain variable (VL) region comprising CDR sequences SEQ ID NOs:
• 4, 5, and 6, respectively;
• b) a heavy chain variable (VH) region comprising the CDR sequences SEQ ID NOs:
• 7, 8, and 9 and a light chain variable region comprising CDR sequences SEQ ID NOs:
• 10, 11 and 12, respectively;
• c) a heavy chain variable (VH) region comprising the CDR sequences SEQ ID NOs:
• 13, 14, and 15 and a light chain variable (VL) region comprising CDR sequences SEQ ID NOs:
• 16, 17, and 18, respectively;
• d) a heavy chain variable (VH) region comprising the CDR sequences SEQ ID NOs:
• 19, 20, 21 and a light chain variable (VL) region comprising CDR sequences SEQ ID NOs:
• 22, 23, and 24, respectively;
• e) the heavy chain variable (VH) and light chain variable (VL) regions comprising the CDR sequences SEQ ID NOS. 1-3 and 7-9, respectively;
• f) the heavy chain variable (VH) and light chain variable (VL) regions comprising the CDR sequences SEQ ID NOS. 4-6 and 10-12, respectively;
• g) the heavy chain variable (VH) and light chain variable (VL) regions comprising SEQ ID NO. 13 and SEQ ID NO. 14, respectively;
• h) the heavy chain variable (VH) and light chain variable (VL) regions comprising the CDR sequences SEQ ID NOS. 15-17 and 21-23, respectively;
• i) the heavy chain variable (VH) and light chain variable (VL) regions comprising the CDR sequences SEQ ID NOS. 18-20 and 24-26, respectively;
• j) the heavy chain variable (VH) and light chain variable (VL) regions comprising SEQ ID NO. 27 and SEQ ID NO. 28, respectively;
• k) the heavy chain variable (VH) and light chain variable (VL) regions comprising the CDR sequences SEQ ID NOS. 29-31 and 35-37, respectively;
• l) the heavy chain variable (VH) and light chain variable (VL) regions comprising the CDR sequences SEQ ID NOS. 32-34 and 38-40, respectively;
• m) the heavy chain variable (VH) and light chain variable (VL) regions comprising SEQ ID NO. 41 and SEQ ID NO. 42, respectively;
• n) the heavy chain variable (VH) and light chain variable (VL) regions comprising the CDR sequences SEQ ID NOS. 43-45 and 49-51, respectively;
• o) the heavy chain variable (VH) and light chain variable (VL) regions comprising the CDR sequences SEQ ID NOS. 46-48 and 52-54, respectively;
• p) the heavy chain variable (VH) and light chain variable (VL) regions comprising SEQ ID NO. 55 and SEQ ID NO. 56, respectively;
• or a derivative of any one of a)-p);
• wherein the antibody or antigen binding fragment thereof specifically binds to human progranulin (PGRN).