Src inhibitors and uses thereof

A compound of Formula (V) or (VI), or a pharmaceutically acceptable salt thereof:

• wherein:
• Y is CRY or N;
• R3 is —Z1-L1-Z2-L2-R6;
• Z1 is C1-6 aliphatic;
• a 3-7 membered monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• or a 6-10 membered bicyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• wherein Z1 is substituted by m instances of R7, and n instances of R8;
• Z2 is a covalent bond;
• C1-6 aliphatic;
• a 3-7 membered monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• or a 6-10 membered bicyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• wherein Z2 is substituted by m instances of R7, and n instances of R8;
• each of L1 and L2 is independently a covalent bond, —N(H)—, —N(R5)—, or —C(O)—;
• R4 is hydrogen, or an optionally substituted group selected from the group consisting of C1-6 aliphatic, phenyl, a 3-7 membered saturated or partially unsaturated heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and a 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• R6 is —CN,
• each of R6A, R6B, and R6C is independently hydrogen, halogen, —CN, —C(O)R, —C(O)OR, —C(O)NR2, —C(O)N(R)OR, or an optionally substituted group selected from C1-6 aliphatic, phenyl, a 3-7 membered saturated or partially unsaturated heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and a 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• R6D is halogen or —OS(O)2R;
• each instance of R5, R7, R8, and R10 is independently hydrogen or RL;
• each instance of RL is independently oxo, halogen, —CN, —NO2, —OR, —SR, —NR2, —S(O)2R, —S(O)2NR2, —S(O)R, —S(O)NR2, —C(O)R, —C(O)OR, —C(O)NR2, —C(O)N(R)OR, —OC(O)R, —OC(O)NR2, —N(R)C(O)OR, —N(R)C(O)R, —N(R)C(O)NR2, —N(R)C(NR)NR2, —N(R)S(O)2NR2, —N(R)S(O)2R, or an optionally substituted group selected from C1-6 aliphatic, phenyl, a 3-7 membered saturated or partially unsaturated heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and a 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• RY is hydrogen or RL;
• R9 is —R1—X—R2;
• or a ring selected from the group consisting of phenyl;
• a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• and an 8-10 membered bicyclic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• wherein said ring is substituted by p instances of R10;
• R1 is selected from arylene and heteroarylene;
• each of which is optionally substituted;
• R2 is selected from aryl, heteroaryl, and cycloalkyl;
• each of which is optionally substituted;
• X is a C1-2 bivalent hydrocarbon chain wherein one or more methylene units of the chain are optionally and independently replaced by —CH(RL)—, C3-5 cycloalkylene, —N(R)—, —N(R)C(O)—, —C(O)N(R)—, —N(R)S(O)2—, —S(O)2N(R)—, —O—, —C(O)—, —OC(O)—, —C(O)O—, —S—, —S(O)—, or —S(O)2—;
• each R is independently hydrogen, or an optionally substituted group selected from C1-6 aliphatic, phenyl, a 3-7 membered saturated or partially unsaturated heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and a 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, or:
• two R groups on the same nitrogen are taken together with their intervening atoms to form a 4-7 membered saturated, partially unsaturated, or heteroaryl ring having 0-3 heteroatoms, in addition to the nitrogen, independently selected from nitrogen, oxygen, and sulfur;
• each instance of m and n is independently 0-4;
• and
• p is 0-4.