Inhibitors of naegleria fowleri

A compound of Formula I

• a stereoisomer of thereof, a pharmaceutically acceptable salt of the compound, or a pharmaceutically acceptable salt of the stereoisomer;
• wherein,
• X is CH2, O, or NR2;
• Y is CH2 or CH2CH2, provided that when Y is CH2, X is CH2;
• Z is N or CR7;
• R1 is H, C(O)R9, or a substituted or unsubstituted alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, aralkyl, heterocyclylalkyl, or heteroarylalkyl group;
• R2 is H or an unsubstituted alkyl group;
• R3a, R3b, R4a, and R4b are independently selected from the group consisting of H and a substituted or unsubstituted alkyl group;
• R5 and R8 are independently selected from the group consisting of H, OR10, halogen and a substituted or unsubstituted alkyl, alkenyl, aryl, aralkyl, or heteroaryl group;
• R6 and R7 are independently selected from the group consisting of H, halogen, CN, NO2, C(O)R11, C(O)OR11, C(O)NR11R12, OR12, and a substituted or unsubstituted alkyl, aryl or heteroaryl group;
• R9 is substituted or unsubstituted alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl group;
• and
• R10, R11, and R12 at each occurrence are independently H or an unsubstituted alkyl group.