Back to results
US 2025/0154104 A1Published application
Small molecules for treating cancer, inhibiting chemokine activity and/or inducing cell death
AssigneeAlonBio Ltd.
InventorsAmnon PELED, Michal ABRAHAM KARNI, Orly EIZENBERG
Life of this patent
Estimating the term…
Abstract
Compounds capable of, or usable in, inducing death of cancer cells and/or modulating a biological activity of a chemokine e.g., cell migration, and/or treating diseases and disorders associated with a biological activity of a chemokine and/or cell migration, and/or in treating cancer, are provided herein. The compounds are collectively represented by Formulae Ia or Ib: wherein A, B, D, E, G and R1-R5 are as defined in the specification, with one or more of D, E and G, preferably E, is hydroxy.
Claims19
A compound represented by Formula Ia and/or Ib:
- wherein:
- A is an alkyl being at least 4 carbon atoms in length;
- B is selected from hydroxy and alkoxy;
- D and G are each independently selected from hydrogen, hydroxy, alkoxy and alkyl, provided that at least one of D and G is hydrogen;
- E is hydroxy;
- R1 is selected from hydrogen and alkyl;
- and
- each of R2-R5 is independently selected from hydrogen, hydroxy, halo, alkoxy, thioalkoxy, thiol, thioalkoxy and amine.
5 more elements
Dependencies are inferred from the claim text.