Deuterated tryptamine derivatives and methods of use

A compound of Formula (I),

• or an optically pure stereoisomer, pharmaceutically acceptable salt, or solvate thereof,
• wherein:
• X1 and X2 are deuterium;
• Y1 and Y2 are deuterium;
• R is
• R2 is selected from hydrogen, deuterium, unsubstituted or substituted alkyl, unsubstituted or substituted allyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted aryl, and unsubstituted or substituted heteroaryl;
• R4 is selected from hydrogen and deuterium;
• R5 is selected from hydrogen and deuterium;
• R6 is selected from hydrogen and deuterium;
• R7 is selected from hydrogen and deuterium;
• R8 is an alkyl substituted with one or more deuterium;
• R9 is an alkyl substituted with one or more deuterium;
• and
• R10 is selected from hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted allyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted aryl, and unsubstituted or substituted heteroaryl.