Continuous flow synthesis of mesoporous silica particles

A continuous process for synthesizing mesoporous silica particles, the continuous process comprising:

• (a) preparing a first reaction mixture and a second reaction mixture at an inlet of a reactor, the first reaction mixture comprising a surfactant, a reducing agent, water, and methanol, the second reaction mixture comprising an orthosilicate, 1,2,4-trimethylbenzene (TMB), and methanol;
• (b) passing and mixing the first reaction mixture and the second reaction mixture inside the reactor for a residence time from 10 minutes to 30 minutes at a temperature from 20° C. to 75° C.;
• and
• (c) continuously running (b) for a time period of 2 hours to 4 hours to obtain the mesoporous silica particles;
• wherein a contact angle between a surface of the reactor and the reaction mixtures inside the reactor during (b) and (c) is from 30° to 170°.