Fluid control adapters

A modular microfluidic flow cell array, comprising:

• a fluid directing body defining a plurality of body microfluidic channels fluidically connecting source fluid openings with distal body openings at a distal body surface;
• a first fluid control adapter including a first adapter microfluidic channel fluidically connecting one or more proximal adapter openings defined by a first proximal adapter surface with one or more distal adapter openings defined by a first distal adapter surface, wherein the first proximal adapter surface is removably connectable with the distal body surface of the fluid directing body;
• and
• an applicator tip removably connectable with the first distal adapter surface ofthe first fluid control adapter,
• wherein when the fluid directing body, the first fluid control adapter, and the applicator tip are fluidically connected, the substance applied to an application surface occurs as fluid passes from the fluid directing body, through the first fluid control adapter, and through the applicator tip depositing the substance to the application surface.

A method of treating an application surface for analysis of a substance, comprising:

• docking a first modular microfluidic flow cell array on an application surface, wherein the first modular microfluidic flow cell array includes a fluid directing body fluidly connected to a first fluid control adapter;
• flowing a first fluid through the first modular microfluidic flow cell array including through the first fluid control adapter;
• removing the first fluid control adapter from the fluid directing body;
• fluidly connecting a second fluid control adapter to the fluid directing body to form a second modular microfluidic flow cell array;
• docking the second modular microfluidic flow cell array on the application surface;
• and
• flowing a second fluid through the second modular microfluidic flow cell array including through the second fluid control adapter.

The method of claim 91, wherein the interrogation fluid is:

• applied on unspotted space on the application surface surrounding the plurality of spots or all of the spots of the first group of substance spots, the second group of substances spots, or both;
• applied using an interrogation applicator tip that is fluidically connectable directly or indirectly to the fluid directing body;
• fluidically connectable and disconnectable by mechanical, magnetic, or electrostatic force engagement and disengagement;
• or
• a combination thereof.