Closed Loop DBS Using Evoked Potentials
AssigneeBoston Scientific Neuromodulation Corporation
InventorsTianhe Zhang, Rosana Esteller
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Abstract
Methods and systems for optimizing and/or maintaining stimulation during deep brain stimulation (DBS) are described. The methods and systems involve determining evoked neural responses, namely evoked resonant neural activity (ERNA) evoked in a patient's brain by the stimulation. ERNA features corresponding to the patient's brain state during the absence and during the presence of therapeutic stimulation are determined. The ERNA features are used to guide and to maintain stimulation parameters for therapeutic stimulation.
Claims20
A method for providing deep brain stimulation (DBS) to a patient's brain using one or more electrode leads implanted in the patient's brain, wherein each of the one or more electrode leads comprises a plurality of electrodes configured to contact the patient's brain tissue, the method comprising:
- using one or more of the electrodes to provide non-therapeutic stimulation to the patient's brain, wherein the non-therapeutic stimulation is configured to evoke first evoked neural resonant activity (ERNA) in the patient's brain and is not configured to treat the patient's symptoms,
- using one or more of the electrodes to record first signals in the patient's brain indicative of the first ERNA, wherein the first ERNA is indicative of the patient's brain state in the absence of therapeutic stimulation,
- using one of more of the electrodes to provide therapeutic stimulation to the patient's brain, wherein the therapeutic stimulation is configured to treat the patient's symptoms,
- using one or more of the electrodes to record second signals indicative of second ERNA, wherein the second ERNA is indicative of the patient's brain state in the presence of therapeutic stimulation,
- comparing the first ERNA and the second ERNA, and
- configuring the therapeutic stimulation based on the comparison.
Dependencies are inferred from the claim text.