Method for the treatment of vascular anomalies by administering one or more sclerosing agents and applying a series of electric pulses

A method for treatment of a vascular anomaly in a subject in need thereof comprising:

• (a) administering one or more sclerosing agents to the subject in need thereof by systemic or local injection such that the one or more sclerosing agents are delivered to the vascular anomaly;
• and
• (b) applying to the subject in need thereof at the site of the vascular anomaly, a series of electric pulses having an energy, defined as number of pulses×voltage of each pulse×duration of pulse, and being in a range from 15 to 25 Joule for inducing electroporation,
• wherein the application of pulses is effective to increase effectiveness of the one or more sclerosing agents or to reduce local and systemic toxicity or side effects of the one or more sclerosing agents, relative to a subject that suffers a vascular anomaly but to whom the effective electrical pulses were not applied.