Chemical-based nitric oxide gas-generating drug device for delivery to a patient

A two-stage dilution system for delivering NO to a patient, the system comprising:

• a removable NO gas cartridge in fluid communication with a gas mixing chamber and a CPU,
• wherein the gas mixing chamber comprises a carrier gas inlet, an NO inlet, a mixing space, and a gas outlet;
• wherein the NO inlet comprises an NO nozzle having an internal diameter of about 10 μm to 50 μm,
• wherein concentrated NO gas is delivered from the NO gas cartridge to the gas mixing chamber via a gas manifold, and wherein the pressure of the NO gas in the manifold is controlled by an electronic pressure regulator in communication with the CPU,
• wherein a carrier gas selected from air or N2 flows into the carrier gas inlet at a fixed flow rate,
• and wherein the NO nozzle injects the NO into a stream of carrier gas to mix the gas in the mixing chamber to form a first diluted mixed gas comprised of NO diluted in the carrier gas, wherein the mixed gas comprises less than 1000 ppm of NO and less than 25 ppb of NO2.

A system for delivering NO to a patient, the system comprising:

• a removable NO gas cartridge in fluid communication with a gas mixing chamber and a CPU,
• wherein the gas mixing chamber comprises a carrier gas inlet, an NO inlet, a mixing space, and a gas outlet;
• wherein the NO inlet comprises an NO nozzle having an internal diameter of about 10 μm to 50 μm
• wherein concentrated NO gas is delivered from the NO gas cartridge to the gas mixing chamber via a gas manifold, and wherein the pressure of the NO gas in the manifold is controlled by an electronic pressure regulator in communication with the CPU,
• and wherein the NO nozzle injects the NO into a stream of carrier gas to mix the gas in the mixing chamber to form a mixed gas comprised of NO diluted in carrier gas, wherein the mixed gas comprises from 1 ppm to 1000 ppm.

A device for on-demand generation of NO, the device comprising:

• a reaction vessel and a liquid storage component, wherein the reaction vessel comprises a liquid injection port and a gas exit port;
• wherein the liquid injection port and a gas exit port are each fitted with a self-sealing plug connectors pressure-tolerant up to 500 PSI such that the reaction vessel is self-sealing and pressure-tolerant up to 500 PSI;
• and
• wherein the liquid storage component is removably coupled to the reaction vessel at the liquid injection port via a socket connector.