Autologous cell based sars-cov-2 vaccines
AssigneeOrgenesis Inc.
InventorsOren MOSKOVICH, Shlomo SRAGOVICH, Irit MEIVAR-LEVY
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Abstract
Disclosed herein are multi-antigenic autologous, cell-based SARS-CoV-2 vaccines comprising autologous antigen presenting cells (APCs) displaying at least two different SARS-CoV-2 antigens. These vaccines can be used to prevent SARS-CoV-2 infection or COVID-19. Further disclosed are methods for producing and using the vaccines.
Claims37
A multi-antigenic autologous, cell-based SARS-CoV-2 vaccine, said vaccine comprising autologous antigen presenting cells (APCs) displaying at least two different SARS-CoV-2 antigens.
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A method for producing a multi-antigenic autologous, cell-based SARS-CoV-2 vaccine, comprising autologous antigen presenting cells (APCs) displaying at least two different SARS-CoV-2 antigens, said method comprising:
- (a) obtaining a population of peripheral blood mononuclear cells (PBMCs) from a subject;
- (b) isolating and culturing APCs from said population of PBMCs;
- (c) contacting said APCs with a preparation of SARS-CoV-2 particles or with mRNAs encoding SARS-CoV-2 antigens for a time period sufficient to generate APCs displaying at least two different SARS-CoV-2 antigens;
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- (d) optionally isolating and expanding said APCs from step (c).
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A method for preventing or treating a SARS-CoV-2 infection in a subject, the method comprising:
- (a) obtaining a population of peripheral blood mononuclear cells (PBMCs) from a subject;
- (b) isolating and culturing APCs from said population of PBMCs;
- (c) contacting said APCs with a preparation of SARS-CoV-2 particles or with mRNAs encoding SARS-CoV-2 antigens for a time period sufficient to generate APCs displaying at least two different SARS-CoV-2 antigens;
- (d) optionally isolating and expanding said APCs from step (c);
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- (e) administering said APCs to said subject.
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Dependencies are inferred from the claim text.