Vaccine against leptospirosis
AssigneeYale University
InventorsElsio Wunder, Albert Ko
Life of this patent
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Abstract
The disclosure provides a composition comprising an effective amount of a plurality of leptospiral proteins, or immunogenic fragments thereof. The disclosure further provides a method of generating an immune response against leptospirosis using a composition comprising the plurality of leptospiral proteins, or immunogenic fragments thereof, and an adjuvant.
Claims19
A composition comprising a plurality of leptospira peptides, each leptospira peptide having 80% or greater sequence identity to one of SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, or SEQ ID NO:
- 8.
A method of conditioning an immune response against leptospirosis in a subject, the method comprising administering to the subject an effective amount of a composition comprising a plurality of leptospira peptides, each leptospira peptide having 80% or greater sequence identity to one of SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 3. SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, or SEQ ID NO:
- 8.
Dependencies are inferred from the claim text.