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US 2025/0152687 A1Published application
Consensus sequence of the antigen telomerase and the use thereof in preventive and therapeutic vaccination
AssigneeEvviVax S.r.l.
InventorsLuigi AURISICCHIO, Antonella CONFORTI
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Abstract
A consensus sequence of the antigen telomerase (ConTRt) can be generated and used in preventive and therapeutic vaccination. The consensus sequence of telomerase was generated by the fusion of two sequences, one belonging to human telomerase (hTERT) and the other to dog telomerase (dTERT), with the aim of developing an effective vaccine for the treatment of tumors expressing both human and dog telomerase, hence in both the human and veterinary sectors.
Claims22
An amino acid sequence of the antigen telomerase, wherein the amino acid sequence being selected from the group consisting of:
- an amino acid consensus sequence of the antigen telomerase comprising sequence SEQ ID NO:1;
- a chimeric amino acid sequence of dog and human telomerase comprising sequence SEQ ID NO:2, or
- a chimeric amino acid sequence of human and dog telomerase comprising sequence SEQ ID NO:3, preferably an amino acid consensus sequence of the antigen telomerase comprising sequence SEQ ID NO:1.
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Dependencies are inferred from the claim text.