Synnotch receptor and use thereof

A chimeric polypeptide, comprising:

• an extracellular region having an activity of binding to a first molecule;
• a transmembrane region, an N-terminus of the transmembrane region being linked to a C-terminus of the extracellular region;
• and
• an intracellular region, an N-terminus of the intracellular region being linked to a C-terminus of the transmembrane region,
• wherein the transmembrane region comprises an isolated polypeptide, the isolated polypeptide having at least 80% identity with a transmembrane region of a Notch receptor protein derived from Xenopus tropicalis;
• wherein the first molecule comprises at least one of a tumor antigen, a virus, a bacterium, an endotoxin, an antibody, a cell receptor, and a ligand of a cell receptor.