Tcr targeting cytomegalovirus antigen, t cell expressing tcr, and application
AssigneeShanghai General Hospital
InventorsPengran WANG, Lianghua SHEN, Yan ZHANG, Xianmin SONG
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Abstract
The present invention provides a T cell receptor (TCR) targeting a cytomegalovirus (CMV) antigen, a T cell expressing the TCR, and an application. Specitically, disclosed in the present invention are a specific T cell for HLA-A*0201-restricted targeting of a CMV-pp65 antigenic epitope and an application thereof. The TCR carried by the T cell can specifically target CMV-pp65, and clear the CMV precisely and quickly.
Claims14
1-14. (canceled)
A T cell receptor (TCR), wherein the T cell receptor comprises a TCR α chain variable domain and a TCR β chain variable domain, and the amino acid sequence of CDR3 of the TCR α chain variable domain is CAFPYNNNDMRF (SEQ ID No. 13);
- and
- the amino acid sequence of CDR3 of the TCR β chain variable domain is CASSLEGYTEAFF (SEQ ID No. 21).
Dependencies are inferred from the claim text.