Compositions for vitamin d production
AssigneeDr Weller Limited
InventorMichael FINNEN
Life of this patent
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Abstract
The present disclosure provides compositions which may be useful in the generation of vitamin D and/or nitric oxide, in particular when exposed to radiation (e.g. light and/or UV radiation). The disclosure further provides methods of generating vitamin D2 and/or nitric oxide, and methods of treating and/or preventing conditions and/or diseases associated with and/or caused by a vitamin D and/or nitric oxide deficiency.
Claims33
A composition for use in facilitating, augmenting and/or promoting the generation of vitamin D2, wherein the composition:
- (i) comprises ergosterol;
- and
- (ii) is formulated for topical administration.
A composition comprising:
- (i) one or more UV-protecting and/or sunlight-protecting components;
- and
- (ii) ergosterol.
The composition of any one of the preceding claims, further comprising:
- (iii) one or more promoter agents to augment, promote and/or enhance the generation of vitamin D2.
The composition of any one of the preceding claims, wherein the one or more promoter agents is selected from a thiol compound, a disulfide compound, an NO-precursor compound and a liposome, such as a phospholipid.
A composition comprising:
- (i) ergosterol;
- (ii) a thiol and/or a disulfide compound (e.g. glutathione);
- and
- (iii) a NO-precursor compound (e.g. a metal nitrate such as sodium nitrate);
- optionally wherein the composition further comprises:
- (iv) a liposome (e.g. a phospholipid);
- and/or
- (v) one or more UV-protecting and/or sunlight-protecting components.
The composition of any one of the preceding claims, wherein the composition comprises between about 0.0001 wt % and about 25 wt %, or between about 0.0075 wt % and about 1 wt % or about 0.1 wt % of ergosterol based on the total weight of the composition.
The composition of any one of the preceding claims, wherein an NO-precursor compound is present and the composition comprises between about 0.01 wt % and about 1 wt %, between about 0.05 wt % and about 0.5 wt %, or between about 0.075 wt % and about 0.2 wt % of the NO-precursor compound based on the total weight of the composition.
The composition of any one of the preceding claims, wherein a thiol or disulfide compound is present and the composition comprises between about 0.01 wt % and about 1 wt %, between about 0.05 wt % and about 0.5 wt %, or between about 0.075 wt % and about 0.2 wt % of the thiol or disulfide compound based on the total weight of the composition.
The composition of any one of the preceding claims, which is formulated for topical administration.
The composition of any one of the preceding claims, further comprising one or more pharmaceutically, therapeutically and/or cosmetically acceptable diluents, excipients or carriers.
Ergosterol for use in a method for treating and/or preventing diseases or conditions associated with reduced levels of vitamin D and/or a vitamin D deficiency, said method comprising topically administering to a subject in need thereof a therapeutically effective amount of ergosterol.
Dependencies are inferred from the claim text.