Modulation of aversive and salt tastes
OwnerYuki Oka, Yameng Zhanginventors
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Abstract
Disclosed herein include methods and compositions suitable for use in modulation of aversive taste tolerance. In some embodiments, ingestion of sodium and/or aversive substances is reduced. Also disclosed include methods for identifying modulators for aversive taste tolerance.
Claims38
A method of reducing aversive taste tolerance in a subject in need thereof, the method comprising:
- inhibiting a plurality of prostaglandin receptor type 3 (Ptger3)-positive neurons in the lamina terminalis (LTPtger3-neurons) of the subject, thereby reducing aversive taste tolerance in the subject.
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A method of increasing aversive taste tolerance in a subject in need thereof, the method comprising:
- stimulating a plurality of prostaglandin receptor type 3 (Ptger3)-positive neurons in the lamina terminalis (LTPtger3-neurons) of the subject, thereby increasing aversive taste tolerance in the subject.
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A method of identifying a modulator of aversive taste tolerance, the method comprising:
- (a) contacting a candidate compound with a plurality of prostaglandin receptor type 3 (Ptger3)-positive neurons in the lamina terminalis (LTPtger3-neurons) to determine an electrophysiological response in the LTPtger3-neurons;
- (b) identifying the candidate compound as a modulator of the LTPtger3-neurons if the electrophysiological response in the LTPtger3-neurons contacted with the candidate compound is altered as compared to the electrophysiological response in the LTPtger3-neurons prior to contacting with the candidate compound;
- (c) administering the identified modulator of the LTPtger3-neurons to a subject;
- (d) assessing the change in valence toward sodium and/or one or more aversive substances of the subject in response to the administration of the identified modulator of the LTPtger3-neurons;
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- (e) identifying the identified modulator of the LTPtger3-neurons as a modulator for aversive taste tolerance if the identified modulator of the LTPtger3-neurons changes the valence toward sodium and/or one or more aversive substances of the subject compared to a control.
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Dependencies are inferred from the claim text.