Anti-coronavirus effect and application of p14k inhibitor
OwnerHangping Yao, Fude Huang +6inventors
InventorsHangping Yao, Fude Huang, Lanjuan Li, Wenan Wang, Luxiang Cao, Changping Jiao, Nanping Wu, Xiangyun Lu
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Abstract
The use of phenylarsenic oxide and a derivative thereof in the prevention or treatment of coronavirus diseases, meanwhile also provided is the use of a PI4KIIIα specific inhibitor in the prevention or treatment of coronavirus diseases.
Claims23
A method of treating or preventing a coronavirus disease in a subject comprising administering to the subject a PI4KIIIα inhibitor.
6-7. (canceled)
14-15. (canceled)
(canceled)
A method for screening a drug for preventing or treating a coronavirus disease, comprising contacting a drug candidate with a PI4KIIIα protein or nucleic acid or PI4KIIIα, and detecting whether the drug candidate is capable of inhibiting the formation or activity of PI4KIIIα.
A method of treating or preventing a coronavirus disease in a subject comprising administering to the subject a compound of Formula (I)
- wherein each R1 is independently selected from:
- (a) H, halogen, nitro, cyano, hydroxy, amino, carbamoyl, C1-6 alkyl, C2-6 alkynyl, C2-6 alkenyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 alkylene-NH2, C1-6 alkylene-NH—C(O)H, —As(O), —N═NH, N—(C1-6 alkyl)amino, N,N—(C1-6 alkyl)2 amino, —NH—C(O)H, —NH—S(O)2H, —C(O)OH, —OC(O)H, —SH, —S(O)2H, —S(O)2—NH2 or heterocyclyl, and optionally substituted with R2 or R3, wherein the R2 and the R3 are each independently selected from amino, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, N—(C1-6 alkyl)amino, N-(6-12 membered aryl)amino, N,N—(C1-6 alkyl)2 amino, C3-6 cycloalkyl, 6-12 membered aryl or 3-12 membered heterocyclyl, and optionally substituted with one or more halogen, nitro, cyano, hydroxy, amino, carbamoyl, —NH—C(O)—R5, —C(O)OR4, 6-12 membered aryl, C1-6 alkyl, C2-6 alkynyl, C2-6 alkenyl, C1-6 alkoxy, C1-6 haloalkyl, 3-6 membered heterocyclyl, C3-6 cycloalkyl or Bn-O—, R4 is C1-6 alkyl, and optionally substituted with one or more halogen, nitro, cyano, hydroxy, amino, carbamoyl, 6-12 membered aryl, C1-6 alkyl, C2-6 alkynyl, C2-6 alkenyl, C1-6 alkoxy, C1-6 haloalkyl, 3-6 membered heterocyclyl, C3-6 cycloalkyl or Bn-O—, and R5 is selected from H, C1-6 alkyl, C2-6 alkynyl, C2-6 alkenyl, C1-6 alkoxy or C1-6 haloalkyl, and/or
- (b) R1 on two adjacent carbon atoms forms 5-12 membered cycloalkyl, aryl or heterocyclyl, and is optionally substituted with one or more halogen, nitro, cyano, hydroxy, amino, carbamoyl, 6-12 membered aryl, C1-6 alkyl, C2-6 alkynyl, C2-6 alkenyl, C1-6 alkoxy, C1-6 haloalkyl, 3-6 membered heterocyclyl, C3-6 cycloalkyl or Bn-O—,
- wherein n is an integer from 0 to 5.
Dependencies are inferred from the claim text.