Methods for treating immune diseases

A method for the prevention and/or treatment of an immune disease in a subject, comprising administering to the subject an effective amount of a therapeutic agent, wherein the immune disease is autoimmune disease, allergic disease or immune-mediated inflammatory disease, and the therapeutic agent is a compound of formula I, X or XI, or a pharmaceutically acceptable salt or solvate thereof,

• wherein, in the formula I,
• A is
• X1, X2, and X3 are each independently selected from the group consisting of —CR8═ and —N═;
• R8 is selected from the group consisting of hydrogen and halogen;
• R2 is selected from the group consisting of —NO2, —SO2CH3, and —SO2CF3;
• R2a is selected from the group consisting of hydrogen and halogen;
• R3 is selected from the group consisting of hydrogen, —CN, —C≡CH, and —N(R4a)(R4b);
• R4a is selected from the group consisting of optionally substituted C1-6 alkyl, optionally substituted C3-6 cycloalkyl, heterocyclo, heteroalkyl, (cycloalkyl)alkyl, and (heterocyclo)alkyl;
• R4b is selected from the group consisting of hydrogen and C1-4 alkyl;
• and
• Y selected from the group consisting of —CH2— and —O—.