Methods for treating immunodeficiency disease
AssigneeX4 Pharmaceuticals, Inc.
InventorsRobert D. Arbeit, Paula Marie Ragan
Life of this patent
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Abstract
The present invention relates to methods of treating patients with WHIM syndrome or related disorders, such as myelokathexis, in which X4P-001 is administered in order to reduce the activity of CXCR4. The methods demonstrate surprising effectiveness, with comparatively little toxicity.
Claims21
1-20. (canceled)
A method of treating WHIM syndrome in a patient in need thereof by administering:
- i) an effective amount of X4P-001 or a pharmaceutically acceptable salt or a composition thereof;
- and
- ii) an effective amount of an agent selected from the group consisting of granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), and intravenous immunoglobulin (IVIG).
A method of treating myelokathexis associated with a mutation in CXCR4 in a patient in need thereof by administering an effective amount of X4P-001 or a pharmaceutically acceptable salt or composition thereof.
A method of treating WHIM syndrome or myelokathexis in a patient in need thereof by administering an effective amount of X4P-001 or a pharmaceutically acceptable salt or composition thereof.
Dependencies are inferred from the claim text.