Implantable devices for the sustained delivery of an opioid antagonist and methods for treating inflammatory, neuroinflammatory and metabolic disorders

A device for delivery of an opioid antagonist, comprising:

• a device comprising an interior reservoir with an inner diameter, a first end, a second end, and a porous partition, the device dimensioned for subcutaneous implantation into a subject;
• a solid formulation comprising an opioid antagonist and one or more of a binder, a stabilizing excipient, and a lubricant, the solid formulation in the form of a compressed shape with a diameter equal to or greater than 80% of the inner diameter of the interior reservoir,
• wherein the compressed shape when hydrated forms an aqueous phase in the interior reservoir of the device, the aqueous phase comprising dissolved opioid antagonist that is released from the device by diffusion across the porous partition for a period of at least about one month.